Michael A Davies Selected Research

Neoplasm Metastasis (Metastasis)

1/2024	Imipridones inhibit tumor growth and improve survival in an orthotopic liver metastasis mouse model of human uveal melanoma.
1/2024	POLARIS: A phase 2 trial of encorafenib plus binimetinib evaluating high-dose and standard-dose regimens in patients with BRAF V600-mutant melanoma with brain metastasis.
6/2023	Co-Targeting FASN and mTOR Suppresses Uveal Melanoma Growth.
1/2023	The CX3CL1-CX3CR1 chemokine axis can contribute to tumor immune evasion and blockade with a novel CX3CR1 monoclonal antibody enhances response to anti-PD-1 immunotherapy.
1/2023	A distinct pattern of growth and RAC1 signaling in melanoma brain metastasis cells.
1/2023	Clinical Features Associated with Outcomes and Biomarker Analysis of Dabrafenib plus Trametinib Treatment in Patients with BRAF-Mutant Melanoma Brain Metastases.
1/2022	Re-thinking therapeutic development for CNS metastatic disease.
1/2022	Dissecting the treatment-naive ecosystem of human melanoma brain metastasis.
1/2022	Clinical Models to Define Response and Survival With Anti-PD-1 Antibodies Alone or Combined With Ipilimumab in Metastatic Melanoma.
11/2021	Targeted therapy strategies for melanoma brain metastasis.

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Michael A Davies Research Topics

Disease

168	Melanoma (Melanoma, Malignant) 05/2024 - 08/2009
132	Neoplasms (Cancer) 05/2024 - 04/2002
42	Neoplasm Metastasis (Metastasis) 01/2024 - 12/2009
22	Brain Neoplasms (Brain Tumor) 01/2024 - 04/2011
10	Disease Progression 01/2020 - 11/2012
8	Breast Neoplasms (Breast Cancer) 01/2020 - 07/2009
5	Uveal melanoma 11/2023 - 08/2012
3	Carcinogenesis 05/2024 - 07/2009
3	Lung Neoplasms (Lung Cancer) 01/2022 - 01/2012
3	Enterocolitis 01/2022 - 10/2018
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2021 - 11/2016
3	Leukemia 11/2019 - 05/2014
2	Overweight 01/2023 - 01/2018
2	Colitis 01/2022 - 10/2018
2	Renal Cell Carcinoma (Grawitz Tumor) 01/2021 - 11/2016
2	Fever (Fevers) 01/2018 - 01/2017
2	Exanthema (Rash) 01/2018 - 12/2017
2	Thrombocytopenia (Thrombopenia) 01/2017 - 02/2012
2	Intracranial Hemorrhages (Intracranial Hemorrhage) 01/2017 - 08/2012

Drug/Important Bio-Agent (IBA)

37	Proteins (Proteins, Gene)FDA Link 05/2024 - 04/2009
32	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2024 - 11/2010
29	Biomarkers (Surrogate Marker)IBA 04/2024 - 06/2002
24	Immune Checkpoint InhibitorsIBA 10/2023 - 01/2016
16	trametinibIBA 01/2023 - 08/2012
15	dabrafenibIBA 01/2023 - 11/2012
11	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2016
11	IpilimumabIBA 01/2022 - 11/2012
9	Phosphotransferases (Kinase)IBA 11/2023 - 07/2009
9	VemurafenibIBA 01/2018 - 10/2012
8	DNA (Deoxyribonucleic Acid)IBA 01/2023 - 12/2009
7	NivolumabIBA 03/2023 - 01/2018
7	AntibodiesIBA 01/2022 - 12/2010
6	Small Interfering RNA (siRNA)IBA 11/2023 - 11/2010
6	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2022 - 08/2012
6	Messenger RNA (mRNA)IBA 10/2021 - 01/2014
6	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2021 - 04/2002
5	Mitogen-Activated Protein KinasesIBA 11/2023 - 11/2010
5	CytokinesIBA 10/2023 - 05/2012
4	PTEN Phosphohydrolase (PTEN Phosphatase)IBA 01/2023 - 11/2014
4	Dacarbazine (DIC)FDA LinkGeneric 01/2018 - 02/2013
4	Interleukin-2 (IL2)IBA 01/2018 - 01/2012
4	AZD 6244IBA 12/2014 - 11/2010
3	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 11/2023 - 03/2010
3	CTLA-4 AntigenIBA 01/2022 - 01/2017
3	pembrolizumabIBA 01/2022 - 10/2016
3	cyclopropapyrroloindoleIBA 01/2022 - 10/2018
3	MicroRNAs (MicroRNA)IBA 01/2022 - 08/2017
3	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2021 - 03/2010
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2021 - 03/2010
3	Cyclin-Dependent Kinases (cdk Proteins)IBA 01/2020 - 01/2016
3	IACS-010759IBA 01/2020 - 01/2019
3	Estrogen ReceptorsIBA 01/2020 - 01/2016
3	Adrenal Cortex Hormones (Corticosteroids)IBA 04/2019 - 01/2017
3	EnzymesIBA 12/2018 - 06/2010
3	SteroidsIBA 10/2018 - 01/2017
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 10/2018 - 11/2010
3	Neuregulin-1 (Neuregulin 1)IBA 10/2018 - 08/2014
3	Mechanistic Target of Rapamycin Complex 1IBA 01/2018 - 12/2014
3	LigandsIBA 12/2017 - 10/2012
3	Temozolomide (Temodar)FDA LinkGeneric 12/2016 - 08/2014
3	PLX 4720IBA 08/2014 - 01/2013
2	Therapeutic UsesIBA 01/2024 - 11/2017
2	encorafenibIBA 01/2024 - 01/2020
2	binimetinibIBA 01/2024 - 01/2020
2	InterferonsIBA 10/2023 - 08/2014
2	Interleukin-6 (Interleukin 6)IBA 07/2023 - 01/2022
2	relatlimabIBA 03/2023 - 11/2022
2	Dasatinib (BMS 354825)FDA Link 01/2023 - 08/2009
2	Monoclonal AntibodiesIBA 01/2023 - 08/2014
2	Long Noncoding RNAIBA 01/2022 - 06/2016
2	Imatinib Mesylate (Gleevec)FDA Link 12/2021 - 08/2009
2	Metformin (Glucophage)FDA LinkGeneric 01/2021 - 01/2020
2	Tyrosine Kinase InhibitorsIBA 01/2021 - 09/2010
2	Amino Acids FDA Link 01/2020 - 09/2014
2	tyrosine receptor (receptor, tyrosine)IBA 01/2020 - 12/2017
2	Infliximab (Remicade)FDA Link 04/2019 - 10/2018
2	palbociclibIBA 01/2019 - 01/2016
2	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2019 - 11/2016
2	130-nm albumin-bound paclitaxelIBA 11/2018 - 08/2014
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2018 - 04/2002
2	Protein Isoforms (Isoforms)IBA 01/2018 - 01/2017
2	Formaldehyde (Formol)FDA Link 01/2018 - 03/2015
2	ParaffinIBA 01/2018 - 03/2015
2	Proto-Oncogene Proteins B-rafIBA 01/2018 - 09/2013
2	AntigensIBA 10/2017 - 06/2015
2	MitogensIBA 02/2016 - 08/2012
2	NucleotidesIBA 06/2015 - 09/2014
2	Cisplatin (Platino)FDA LinkGeneric 08/2014 - 03/2010
2	temsirolimus FDA Link 02/2013 - 02/2012
2	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 08/2012 - 02/2012
2	lysophosphatidic acidIBA 05/2012 - 06/2010

Therapy/Procedure

113	Therapeutics 05/2024 - 07/2009
35	Immunotherapy 10/2023 - 12/2012
10	Drug Therapy (Chemotherapy) 01/2022 - 03/2010
4	Neoadjuvant Therapy 07/2023 - 06/2015
4	Radiotherapy 07/2023 - 01/2019
3	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2022 - 12/2012
3	Precision Medicine 01/2017 - 01/2016
2	Lymph Node Excision (Lymph Node Dissection) 07/2021 - 11/2014
2	Aftercare (After-Treatment) 12/2020 - 08/2014